Drug Profile

SION 719

Alternative Names: SION-719

Latest Information Update: 13 Aug 2026

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At a glance

Originator Sionna Therapeutics
Class Antifibrotics; Small molecules
Mechanism of Action Cystic fibrosis transmembrane conductance regulator modulators

Orphan Drug Status

Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

No
New Molecular Entity Yes

Highest Development Phases

Discontinued Cystic fibrosis

Most Recent Events

10 Aug 2026 Discontinued - Phase-II for Cystic fibrosis (Adjunctive treatment) in Australia, USA (PO)
10 Aug 2026 Efficacy and adverse events data from the phase II PreciSION CF trial in Cystic fibrosis released by Sionna Therapeutics
25 Jun 2026 Sionna Therapeutics completes the phase IIa PreciSION CF trial in Cystic fibrosis (Adjunctive treatment) in Australia and USA (PO) (NCT07108153)

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