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XB 628

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Drug Profile

XB 628

Alternative Names: XB-628

Latest Information Update: 16 May 2025

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At a glance

  • Originator Invenra
  • Developer Exelixis
  • Class Antineoplastics; Bispecific antibodies; Immunoglobulin fragments; Immunotherapies; Recombinant fusion proteins
  • Mechanism of Action Immunologic cytotoxicity; Natural killer cell stimulants; NK cell lectin-like receptor subfamily C antagonists; Programmed cell death-1 ligand-1 inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Phase I Solid tumours

Most Recent Events

  • 06 May 2025 Phase-I clinical trials in Solid tumours (Recurrent, Late-stage disease, Metastatic disease, Second-line therapy or greater) in USA (IV) (NCT06952010)
  • 25 Apr 2025 Pharmacodynamics data from a preclinical study in Solid tumours presented at the 116th Annual Meeting of the American Association for Cancer Research (AACR-2025)
  • 25 Mar 2025 Exelixis files an IND application with the US FDA for Cancer, prior to March 2025

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