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SIT 047

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Drug Profile

SIT 047

Alternative Names: SIT-047

Latest Information Update: 20 Jan 2026

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At a glance

  • Originator Sitryx
  • Class Antipsoriatics; Antirheumatics
  • Mechanism of Action MTHFD2 protein inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Preclinical Psoriatic arthritis
  • Discontinued Systemic lupus erythematosus

Most Recent Events

  • 20 Jan 2026 Discontinued for Systemic lupus erythematosus in United Kingdom (unspecified route) (Sitryx pipeline, January 2026)
  • 20 Jan 2026 Preclinical trials in Psoriatic arthritis in United Kingdom (PO) (Sitryx pipeline, January 2026)
  • 17 Jan 2023 Early research in Systemic lupus erythematosus in United Kingdom (unspecified route), prior to January 2023 (Sitryx pipeline, January 2023)

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