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Psilocybin - Filament Health

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Drug Profile

Psilocybin - Filament Health

Alternative Names: NPX-5; PEX 010

Latest Information Update: 16 Mar 2026

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At a glance

  • Originator Filament Health
  • Developer Filament Health; John Hopkins University; Psyence Group; Rigshospitalet; University of Calgary
  • Class Analgesics; Anti-infectives; Anti-inflammatories; Antidepressants; Antineoplastics; Antipsychotics; Anxiolytics; Behavioural disorder therapies; Dimethylamines; Drug withdrawal therapies; Ethylamines; Indoles; Mood stabilisers; Neuropsychotherapeutics; Organophosphorus compounds; Phosphates; Phytotherapies; Small molecules
  • Mechanism of Action ATP-binding cassette transporter modulators; Serotonin 5-HT2 receptor agonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Adjustment disorders; Alcoholism; Depressive disorders; Opioid-related disorders; Post-traumatic stress disorders
  • Phase I Brain injuries
  • Preclinical Anxiety disorders

Most Recent Events

  • 01 Feb 2026 Filament Health in collaboration with Trinity College Dublin plans the phase II POSITRON trial for Cocaine related disorders in Ireland (PO), in February 2026 (CTIS2024-515147-32-02) (EUCT2024-515147-32-02)
  • 22 Dec 2025 Phase-II clinical trials in Opioid-related disorders in USA (PO) (NCT06810310)
  • 07 Sep 2025 Filament Health plans to initiate a phase II trial for Depressive disorders (Treatment-resistant) in Italy (PO) (CTIS2024-519844-34-03)

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