Drug Profile

ENX 104

Alternative Names: ENX-104

Latest Information Update: 16 Jan 2026

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At a glance

Originator Engrail Therapeutics
Class Antidepressants; Benzamides; Heterocyclic compounds; Small molecules
Mechanism of Action Dopamine D2 receptor antagonists; Dopamine D3 receptor antagonists

Orphan Drug Status

Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

No
New Molecular Entity Yes

26 Nov 2025 Engrail Therapeutics completes a phase I trial for Major Depressive Disorder in United Kingdom (NCT07253324)
02 Sep 2025 Engrail Therapeutics completes a phase I trial for Healthy volunteers in United Kingdom (PO) (NCT07253272)
03 Apr 2025 Engrail Therapeutics completes a phase I trial in Major depressive disorder (In volunteers) in Netherlands (PO) (EudraCT2024-514265-19-00)

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