Drug Profile

HMBD 501

Alternative Names: ENV-501; ENV-ONC-501; HMBD-501

Latest Information Update: 15 May 2025

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At a glance

Originator Hummingbird Bioscience
Class Alkaloids; Antibodies; Antineoplastics; Camptothecins; Drug conjugates; Immunoconjugates; Immunoglobulin Fc fragments
Mechanism of Action DNA topoisomerase I inhibitors

Orphan Drug Status

Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

No
New Molecular Entity Yes

Highest Development Phases

Phase I/II Solid tumours

Most Recent Events

06 May 2025 Phase-I/II clinical trials in Solid tumours (Late-stage disease, Metastatic disease, Inoperable/Unresectable, Second-line therapy or greater) in Australia, USA (IV) (NCT06956690)
29 Jul 2024 Endeavor BioMedicines plans a clinical trial for solid tumours in 2024
19 Oct 2023 Endeavor BioMedicines in-licenses HMBD 501 from Hummingbird Bioscience

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