Drug Profile

RMC 5127

Alternative Names: RMC-5127

Latest Information Update: 27 Jan 2026

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At a glance

Originator REVOLUTION Medicines
Class Antineoplastics; Small molecules
Mechanism of Action KRAS protein inhibitors

Orphan Drug Status

Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

No
New Molecular Entity Yes

Highest Development Phases

Phase I Solid tumours

Most Recent Events

08 Jan 2026 Phase-I clinical trials in Solid tumours (Late-stage disease, Metastatic disease, Second-line therapy or greater, Combination therapy) in USA (PO) (NCT07349537)
06 Nov 2025 REVOLUTION Medicines plans a first-in-human dose escalation phase I clinical trial of RMC 5127 in quarter one of 2026
25 Apr 2025 Pharmacodynamics and safety data from preclinical trials in Cancer presented at the 116^th Annual Meeting of the American Association for Cancer Research (AACR-2025)

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