Drug Profile

RMC 5127

Alternative Names: RMC-5127

Latest Information Update: 19 Aug 2025

Price :

$50 ^*

Note:

Adis is an information provider. We do not sell or distribute actual drugs.
Final gross price and currency may vary according to local VAT and billing address.
Your purchase entitles you to full access to the information contained in our drug profile at the time of purchase.
A link to download a PDF version of the drug profile will be included in your email receipt.

At a glance

Originator REVOLUTION Medicines
Class Antineoplastics; Small molecules
Mechanism of Action KRAS protein inhibitors; Ras protein inhibitors

Orphan Drug Status

Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

No
New Molecular Entity Yes

Highest Development Phases

Preclinical Cancer

Most Recent Events

06 Aug 2025 REVOLUTION Medicines plans a first-in-human dose escalation phase I clinical trial of RMC 5127 in 2026
25 Apr 2025 Pharmacodynamics and safety data from preclinical trials in Cancer presented at the 116^th Annual Meeting of the American Association for Cancer Research (AACR-2025)
13 Jan 2024 Pharmacodynamics data from a preclinical study in Cancer released by REVOLUTION Medicines (prior to January 2024)

You need to be a logged in or subscribed to view this content

If your organization or you do not have a subscription, try one of the following:

Contacting your organization’s admin about adding this content to your AdisInsight subscription
Buying a PDF version of any individual profile
Request a free trial (opens in a new window)

If your organization has a subscription, there are several access options, even while working remotely:

Working within your organization’s network
Login with username/password or try to access via your institution
Persisted access using your organization’s identifier stored in your user browser for 90 days

For assistance, contact us at asktheexpert.adisinsight@springer.com