Drug Profile

RMC 5127

Alternative Names: RMC-5127

Latest Information Update: 12 Mar 2025

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At a glance

Originator REVOLUTION Medicines
Class Antineoplastics; Small molecules
Mechanism of Action KRAS protein inhibitors

Orphan Drug Status

Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

No
New Molecular Entity Yes

Highest Development Phases

Preclinical Cancer

Most Recent Events

26 Feb 2025 REVOLUTION Medicines plans a first-in-human dose escalation phase I clinical trial of RMC 5127 in 2026
13 Jan 2024 Pharmacodynamics data from a preclinical study in Cancer released by REVOLUTION Medicines (prior to January 2024)
04 Jan 2024 Preclinical trials in Cancer in USA (unspecified route) (REVOLUTION Medicines Pipeline, January 2024)

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