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HLX 43

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Drug Profile

HLX 43

Alternative Names: Anti-PD-L1 ADC; HLX-43

Latest Information Update: 19 Jun 2025

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At a glance

  • Originator Shanghai Henlius Biotech
  • Class Antibodies; Antineoplastics; Drug conjugates; Immunoconjugates; Immunotherapies; Monoclonal antibodies
  • Mechanism of Action DNA topoisomerase I inhibitors; Programmed cell death-1 ligand-1 inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Cervical cancer; Liver cancer; Non-small cell lung cancer; Squamous cell cancer
  • Phase I/II Solid tumours

Most Recent Events

  • 10 Jun 2025 Efficacy and adverse events data from phase Ib/II trial for Solid tumours released by Henlius Biopharmaceuticals
  • 04 Apr 2025 Phase-II clinical trials in Non-small cell lung cancer (Late-stage disease, Metastatic disease) in China (IV) (NCT06907615)
  • 04 Mar 2025 Phase-II clinical trials in Squamous cell cancer (Recurrent, Metastatic disease) in China (IV) (NCT06857279)

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