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Zinilisib - OnKure Therapeutics

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Drug Profile

Zinilisib - OnKure Therapeutics

Alternative Names: OKI-219

Latest Information Update: 08 Jul 2026

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At a glance

  • Originator OnKure Therapeutics
  • Class Amines; Antineoplastics; Benzoic acids; Fluorocarbons; Isoquinolines; Lactams; Piperazines; Small molecules
  • Mechanism of Action Phosphatidylinositol 3 kinase alpha inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Discontinued Breast cancer; Solid tumours

Most Recent Events

  • 08 Jul 2026 Chemical structure information added
  • 16 Apr 2026 Discontinued - Phase-I for Breast cancer (Combination therapy, Late-stage disease, Metastatic disease, Second-line therapy or greater) in Belgium (PO)
  • 16 Apr 2026 Discontinued - Phase-I for Breast cancer (Combination therapy, Late-stage disease, Metastatic disease, Second-line therapy or greater) in France (PO)

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