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RP 1664

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Drug Profile

RP 1664

Alternative Names: RP-1664

Latest Information Update: 07 Jul 2026

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At a glance

  • Originator Repare Therapeutics
  • Class Amines; Antineoplastics; Cyclopropanes; Fluorocarbons; Imidazoles; Pyrazoles; Pyrimidinones; Small molecules; Sulfones
  • Mechanism of Action PLK4 protein inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Phase I Solid tumours

Most Recent Events

  • 07 Jul 2026 Chemical structure information added
  • 28 Jan 2026 Repare Therapeutics has been acquired by XenoTherapeutics
  • 21 Nov 2025 Repare Therapeutics terminates phase I trial in Solid tumours (In adolescents, In the elderly, Late-stage disease, Metastatic disease, Second-line therapy or greater, In adults) in the US and Denmark (PO), due to the sponsor decided to terminate study early (NCT06232408)

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