Adjuvanted imsapepimut and etimupepimut - IO Biotech
Alternative Names: Cylembio; IO102-IO103; PD-L1/IDO peptide vaccineLatest Information Update: 18 Jun 2025
At a glance
- Originator IO Biotech
- Developer IO Biotech; Merck & Co
- Class Antineoplastics; Cancer vaccines; Immunotherapies; Peptide vaccines
- Mechanism of Action Immunostimulants
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Orphan Drug Status
Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.
- New Molecular Entity No
Highest Development Phases
- Phase III Malignant melanoma
- Phase II Bladder cancer; Non-small cell lung cancer; Squamous cell cancer
- Phase I Solid tumours
Most Recent Events
- 25 Apr 2025 Pharmacodynamics data from a preclinical trial in Cancer presented at the 116th Annual Meeting of the American Association for Cancer Research (AACR-2025)
- 09 Jan 2025 IO Biotech completes the enrolment from its Phase-II clinical trials in Squamous cell cancer and Malignant melanoma (Combination therapy, Recurrent, Late-stage disease, Metastatic disease) in USA, Australia, Denmark, France, Germany, Spain (SC) (NCT05280314)
- 12 Nov 2024 IO Biotech plans to submit a Biologics License Application to the US FDA by the end of 2025 for Malignant melanoma