Drug Profile

MHB 018A

Alternative Names: MHB-018A

Latest Information Update: 19 Dec 2025

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At a glance

Originator Minghui Pharmaceutical (Shanghai)
Class Eye disorder therapies; Immunoglobulin Fc fragments; Recombinant fusion proteins; Single-domain antibodies
Mechanism of Action IGF type 1 receptor antagonists

Orphan Drug Status

Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

No
New Molecular Entity Yes

Highest Development Phases

Phase III Graves ophthalmopathy

Most Recent Events

15 Dec 2025 US FDA approves IND application for MHB 018A for phase III trial in Graves ophthalmology
15 Dec 2025 Update efficacy data from the phase II part of the phase I/II trial in Graves ophthalmology released by Minghui Pharmaceuticals
15 Dec 2025 Minghui Pharmaceuticals plans a global phase III trial for Graves ophthalmology in the US (SC) in first half of 2026

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