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HCB 101

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Drug Profile

HCB 101

Alternative Names: HCB-101; HLX-701; SIRPα-Fc fusion protein - HanchorBio

Latest Information Update: 26 Aug 2025

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At a glance

  • Originator HanchorBio
  • Class Antineoplastics; Immunoglobulin Fc fragments; Immunotherapies; Recombinant fusion proteins
  • Mechanism of Action CD47 antigen inhibitors; Phagocyte stimulants
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Haematological malignancies; Solid tumours
  • Phase I/II Non-small cell lung cancer
  • Phase I Non-Hodgkin's lymphoma

Most Recent Events

  • 01 Aug 2025 Phase-I/II clinical trials in Non-small cell lung cancer (Combination therapy, Second-line therapy or greater, Recurrent, Metastatic disease) in Taiwan (IV) (NCT07136545)
  • 01 Jul 2025 HCB-101 licensed to Shanghai Henlius Biotech in Greater China (including Mainland China, Hong Kong, and Macau), Middle East and North Africa
  • 01 Jul 2025 Phase-II clinical trials in Haematological malignancies in China (IV) prior to July 2025

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