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HCB 101

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Drug Profile

HCB 101

Alternative Names: HCB-101; HLX-701; SIRPα-Fc fusion protein - HanchorBio

Latest Information Update: 15 Dec 2025

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At a glance

  • Originator HanchorBio
  • Developer HanchorBio; Shanghai Henlius Biotech
  • Class Antineoplastics; Immunoglobulin Fc fragments; Immunotherapies; Recombinant fusion proteins
  • Mechanism of Action CD47 antigen inhibitors; Phagocyte stimulants
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Haematological malignancies; Solid tumours
  • Phase I/II Colorectal cancer; Non-small cell lung cancer
  • Phase I Non-Hodgkin's lymphoma

Most Recent Events

  • 11 Dec 2025 Efficacy and adverse events data from a phase Ib/IIa trials in Solid tumours released by HanchorBio
  • 11 Dec 2025 Efficacy, pharmacokinetic and adverse events data from a phase I trial in Solid tumours released by HanchorBio
  • 07 Nov 2025 Efficacy and adverse events data from a phase I and phase Ib/IIa trials in Solid tumours released by HanchorBio

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