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SPY 003

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Drug Profile

SPY 003

Alternative Names: PR-014; SPY 003 207; SPY-003

Latest Information Update: 10 Sep 2026

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At a glance

  • Originator Paragon Therapeutics
  • Developer Altasciences; Spyre Therapeutics
  • Class Anti-inflammatories; Monoclonal antibodies
  • Mechanism of Action Interleukin-23 subunit p19 inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Ulcerative colitis
  • Phase I Inflammatory bowel diseases

Most Recent Events

  • 08 Sep 2026 Efficacy and adverse events data from the phase II SKYLINE trial in Ulcerative colitis released by Spyre Therapeutics
  • 08 Jun 2026 Spyre Therapeutics plans a phase II trial for Ulcerative colitis and Inflammatory bowel diseases (Monotherapy, Combination therapy) in USA (NCT07652294)
  • 13 Apr 2026 Efficacy and adverse events data from the phase II SKYLINE trial in Ulcerative colitis released by Spyre Therapeutics

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