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SPY 003

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Drug Profile

SPY 003

Alternative Names: PR-014; SPY 003 207; SPY-003

Latest Information Update: 21 May 2025

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At a glance

  • Originator Paragon Therapeutics
  • Developer Altasciences; Spyre Therapeutics
  • Class Anti-inflammatories; Monoclonal antibodies
  • Mechanism of Action Interleukin-23 subunit p19 inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Phase I Inflammatory bowel diseases

Most Recent Events

  • 08 May 2025 Spyre Therapeutics plans a phase I trial (SC) by February 2026
  • 10 Mar 2025 Phase-I clinical trials in Inflammatory bowel diseases (In volunteers) in Canada (SC) (NCT06873724)
  • 13 Jan 2025 Spyre plans a phase II trial in Ulcerative colitis (Monotherapy, Combination Therapy) (SC, Injection) in 2025

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