Drug Profile

SPY 130

Alternative Names: PR-026; SPY-130; SPY001-SPY003; SPY001/SPY003

Latest Information Update: 26 Sep 2025

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At a glance

Originator Paragon Therapeutics
Developer Paragon Therapeutics; Spyre Therapeutics
Class Anti-inflammatories; Monoclonal antibodies
Mechanism of Action Integrin alpha4beta7 antagonists; Interleukin 23 inhibitors

Orphan Drug Status

Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

No
New Molecular Entity Yes

27 May 2025 Phase-II clinical trials in Ulcerative colitis in Ukraine, Moldova, Serbia and USA (SC) (NCT07012395)
27 May 2025 Phase-II clinical trials in Ulcerative colitis in USA, Ukraine, Moldova and Serbia (IV) (NCT07012395)
19 Feb 2025 Spyre Therapeutics plans a phase II trial for Ulcerative colitis in the mid 2025

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