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SPY 120

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Drug Profile

SPY 120

Alternative Names: PR-022 - Spyre Therapeutics; SPY-120; SPY001-SPY002; SPY001/SPY002

Latest Information Update: 26 Sep 2025

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At a glance

  • Originator Paragon Therapeutics
  • Developer Paragon Therapeutics; Spyre Therapeutics
  • Class Anti-inflammatories; Monoclonal antibodies
  • Mechanism of Action Integrin alpha4beta7 antagonists; Tumour necrosis factor ligand superfamily member 15 inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Ulcerative colitis
  • Preclinical Inflammatory bowel diseases

Most Recent Events

  • 27 May 2025 Phase-II clinical trials in Ulcerative colitis in Ukraine, Moldova, Serbia and USA (IV) (NCT07012395)
  • 27 May 2025 Phase-II clinical trials in Ulcerative colitis in Ukraine, Moldova, Serbia and USA (SC) (NCT07012395)
  • 19 Feb 2025 Pharmacodynamics data from a preclinical study in Inflammatory bowel disease released by Spyre Therapeutics

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