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KIO 104

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Drug Profile

KIO 104

Alternative Names: KIO-104

Latest Information Update: 27 Mar 2025

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At a glance

  • Originator Kiora Pharmaceuticals
  • Class Anti-inflammatories; Eye disorder therapies; Small molecules
  • Mechanism of Action Dihydroorotate dehydrogenase inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Uveitis
  • New Molecular Entity Yes

Highest Development Phases

  • Phase I/II Uveitis
  • Preclinical Proliferative vitreoretinopathy

Most Recent Events

  • 14 Feb 2025 Kiora Pharmaceuticals plans the phase II KLARITY-1 trial for Retinal oedema (Treatment-experienced) in Australia (Intravitreous, Injection), in April 2025 , (NCT06825702)
  • 04 Sep 2024 Preclinical trials in Proliferative vitreoretinopathy in USA (Intravitreous) prior to September 2024 (Kiora Pharmaceuticals pipeline, September 2024)
  • 21 Aug 2023 Kiora Pharmaceuticals anticipates to discuss the development path for KIO 104 in posterior non-infectious Uveitis with the US FDA in a type 2 pIND meeting in Q3 2024

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