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ISM 6331

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Drug Profile

ISM 6331

Alternative Names: ISM-6331; TEAD transcription factors targeting therapeutic - InSilico Medicine

Latest Information Update: 06 Aug 2026

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At a glance

  • Originator InSilico Medicine
  • Class Antineoplastics; Small molecules
  • Mechanism of Action TEA domain transcription factor inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Mesothelioma
  • New Molecular Entity Yes

Highest Development Phases

  • Phase I Mesothelioma; Solid tumours

Most Recent Events

  • 29 Jul 2026 ISM 6331 receives Fast track status from the US FDA for Mesothelioma (Late stage disease, Inoperable/Unresectable, Second-line therapy or greater)
  • 30 Dec 2024 Phase-I clinical trials in Mesothelioma (Inoperable/Unresectable, Late-stage disease, Metastatic disease, Second-line therapy or greater) in USA (PO) (NCT06566079)
  • 30 Dec 2024 Phase-I clinical trials in Solid tumours (Inoperable/Unresectable, Late-stage disease, Metastatic disease, Second-line therapy or greater) in USA (PO) (NCT06566079)

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