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ISM 5043

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Drug Profile

ISM 5043

Alternative Names: ISM-5043; ISM024-148; KAT6-selective inhibitor - InSilico Medicine; MEN-2312

Latest Information Update: 14 Nov 2024

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At a glance

  • Originator InSilico Medicine
  • Developer InSilico Medicine; Stemline Therapeutics
  • Class Antineoplastics; Small molecules
  • Mechanism of Action KAT6A protein inhibitors; KAT6B protein inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes
  • Available For Licensing Yes

Highest Development Phases

  • Phase I Breast cancer
  • Preclinical HER2 negative breast cancer

Most Recent Events

  • 25 Oct 2024 Phase-I clinical trials in Breast cancer (Combination therapy, Late-stage disease) in France, USA (PO) (NCT06638307)
  • 25 Oct 2024 Phase-I clinical trials in Breast cancer (Monotherapy, Late-stage disease) in France, USA (PO) (NCT06638307)
  • 04 Jan 2024 Stemline Therapeutics in-licenses ISM 5043 from Insilico Medicine

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