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ISM 5043

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Drug Profile

ISM 5043

Alternative Names: ISM-5043; ISM024-148; KAT6-selective inhibitor - InSilico Medicine

Latest Information Update: 08 Jan 2024

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At a glance

  • Originator InSilico Medicine
  • Class Antineoplastics; Small molecules
  • Mechanism of Action KAT6A protein inhibitors; KAT6B protein inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes
  • Available For Licensing Yes

Highest Development Phases

  • Preclinical HER2 negative breast cancer

Most Recent Events

  • 04 Jan 2024 Stemline Therapeutics in-licenses ISM 5043 from Insilico Medicine
  • 05 Dec 2023 Pharmacodynamics and adverse events data from preclinical studies in Breast cancer presented at the 46th Annual San Antonio Breast Cancer Symposium (SABCS-2023)
  • 14 Aug 2023 InSilico Medicine intends to file an IND application for ISM 5043 for the treatment of Her-2 negative breast cancer in the first half of 2024 (InSilico Medicine Pipeline, August 2023)

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