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RG 6457

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Drug Profile

RG 6457

Alternative Names: RG-6457; RO 7589831; VVD 214; VVD-133214

Latest Information Update: 13 Jun 2025

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At a glance

  • Originator Roche
  • Developer Roche; Vividion Therapeutics
  • Class Antineoplastics; Small molecules
  • Mechanism of Action Werner syndrome helicase inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Phase I Solid tumours

Most Recent Events

  • 04 Jun 2025 RG 6457 licensed to Vividion Therapeutics worldwide for the treatment of Solid tumours
  • 25 Jan 2024 Phase-I clinical trials in Solid tumours (Inoperable/Unresectable, Late-stage disease, Metastatic disease, Monotherapy, Second-line therapy or greater) in South Korea, Australia (PO) (NCT06004245)
  • 25 Jan 2024 Phase-I clinical trials in Solid tumours (Inoperable/Unresectable, Late-stage disease, Metastatic disease, Monotherapy, Second-line therapy or greater) in Belgium, Canada, Denmark, Spain, United Kingdom (PO) (NCT06004245), France (PO) (NCT06004245)

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