Drug Profile

XB 371

Alternative Names: XB-371

Latest Information Update: 22 Aug 2025

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At a glance

Originator Catalent; Exelixis
Developer Exelixis
Class Antineoplastics; Drug conjugates; Immunoconjugates; Monoclonal antibodies
Mechanism of Action DNA topoisomerase I inhibitors

Orphan Drug Status

Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

No
New Molecular Entity Yes

Highest Development Phases

Phase I Solid tumours

Most Recent Events

11 Aug 2025 Phase-I clinical trials in Solid tumours (Late-stage disease, Metastatic disease, Recurrent) in USA (IV) (NCT07123103)
13 May 2025 Pharmacodynamics data from a preclinical trial in Cancer released by Exelixis
25 Apr 2025 Pharmacodynamics data from a preclinical study in Cancer presented at the 116th Annual Meeting of the American Association for Cancer Research (AACR-2025)

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