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LY 4066434

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Drug Profile

LY 4066434

Alternative Names: LY-4066434

Latest Information Update: 24 Jun 2025

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At a glance

  • Originator Loxo Oncology
  • Class Antineoplastics; Small molecules
  • Mechanism of Action KRAS protein inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Phase I Solid tumours

Most Recent Events

  • 25 Apr 2025 Pharmacodynamics data from a preclinical trial in Solid tumours presented at the 116th Annual Meeting of the American Association for Cancer Research (AACR-2025)
  • 10 Oct 2024 Phase-I clinical trials in Solid tumours (Metastatic disease, Late-stage disease, Inoperable/Unresectable, Combination therapy) in USA (PO) (NCT06607185)
  • 10 Oct 2024 Phase-I clinical trials in Solid tumours (Metastatic disease, Late-stage disease, Inoperable/Unresectable, Monotherapy) in USA (PO) (NCT06607185)

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