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UP 421

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Drug Profile

UP 421

Alternative Names: HIP-pancreatic islet cell therapy - Sana Biotechnology; UP-421

Latest Information Update: 30 Jun 2025

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At a glance

  • Originator Sana Biotechnology
  • Class Antihyperglycaemics; Gene therapies; Induced pluripotent stem cell therapies
  • Mechanism of Action HLA antigen modulators; Pancreatic beta cell replacements
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity No

Highest Development Phases

  • Phase I Type 1 diabetes mellitus

Most Recent Events

  • 23 Jun 2025 Pharmacodynamics and adverse events data from a phase I trial in Type 1 diabetes released by Sana Biotechnology
  • 07 Jan 2025 Pharmacodynamics and adverse events data from a phase I trial in Type 1 diabetes released by Sana Biotechnology
  • 09 Sep 2024 Efficacy and adverse event data from Type 1 diabetes mellitus presented at the 60th Annual Meeting of the European Association for the Study of Diabetes (EASD-2024)

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