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GEN 1059

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Drug Profile

GEN 1059

Alternative Names: BNT 314; GEN-1059

Latest Information Update: 19 Jun 2025

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At a glance

  • Originator BioNTech; Genmab
  • Class Antineoplastics; Bispecific antibodies; Immunotherapies
  • Mechanism of Action Antibody-dependent cell cytotoxicity; CD137 antigen agonists; T lymphocyte stimulants
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Phase I/II Solid tumours

Most Recent Events

  • 25 Apr 2025 Pharmacodynamics data from preclinical studies in Solid tumours presented at the 116th Annual Meeting of the American Association for Cancer Research (AACR-2025)
  • 24 Apr 2025 Pharmacodynamics data from a preclinical study in Solid tumours released by BioNTech
  • 01 Dec 2023 BioNTech plans a phase I/II trial for Solid tumours (Monotherapy, Combination therapy, Late-stage disease) in USA (IV, Infusion) (NCT06150183)

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