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SAR 445399

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Drug Profile

SAR 445399

Alternative Names: Anti-IL1R3 mAb - Sanofi; MAB-212; SAR-445399

Latest Information Update: 28 Jan 2026

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At a glance

  • Originator MAB Discovery; Sanofi
  • Developer Sanofi
  • Class Anti-inflammatories; Monoclonal antibodies
  • Mechanism of Action Interleukin-1 receptor accessory protein modulators
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Hidradenitis suppurativa
  • Phase I Inflammation

Most Recent Events

  • 29 Dec 2025 Phase-II clinical trials in Hidradenitis suppurativa (Treatment-resistant) in USA (Parenteral, Infusion) (NCT07225569)
  • 29 Dec 2025 Phase-II clinical trials in Hidradenitis suppurativa (Treatment-resistant) in USA (Parenteral, Injection) (NCT07225569)
  • 06 Nov 2025 Sanofi plans a phase II CLAROS trial for Hidradenitis suppurativa in Hungary (Parenteral, Injection/infusion) in December 2025 (NCT07225569)

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