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JNJ 86974680

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Drug Profile

JNJ 86974680

Alternative Names: JNJ-4680; JNJ-86974680

Latest Information Update: 12 Jan 2026

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At a glance

  • Originator Johnson & Johnson Innovation
  • Developer Janssen Research & Development; Johnson & Johnson Innovation
  • Class Antineoplastics; Small molecules
  • Mechanism of Action Adenosine A2A receptor antagonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Phase I Non-small cell lung cancer; Prostate cancer

Most Recent Events

  • 30 Dec 2025 Phase-I clinical trials in Prostate cancer (Combination therapy, Late-stage disease, Hormone refractory, Metastatic disease) in USA (PO) (NCT07319871)
  • 25 Apr 2025 Pharmacokinetics, pharmacodynamics and adverse events data from phase I clinical trials in Non-small cell lung cancer 116th Annual Meeting of the American Association for Cancer Research (AACR-2025)
  • 13 Nov 2023 Phase-I clinical trials in Non-small cell lung cancer (Late-stage disease, Combination therapy) in USA (PO) (NCT06116786)

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