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REM 422

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Drug Profile

REM 422

Alternative Names: REM-422

Latest Information Update: 26 Aug 2026

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At a glance

  • Originator Remix Therapeutics
  • Class Antineoplastics; Small molecules
  • Mechanism of Action Proto-oncogene protein c-myb expression inhibitors; RNA degraders
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Adenoid cystic carcinoma; Acute myeloid leukaemia
  • New Molecular Entity Yes

Highest Development Phases

  • Phase I/II Adenoid cystic carcinoma
  • Phase I Acute myeloid leukaemia; Myelodysplastic syndromes

Most Recent Events

  • 02 Jun 2026 Final pharmacodynamics and efficacy data from a phase I/II ARIA trial in Adenoid cystic carcinoma presented at the 62nd Annual Meeting of the American Society of Clinical Oncology (ASCO-2026)
  • 21 May 2026 Efficacy and adverse events data from a phase I/II ARIA trial in Adenoid cystic carcinoma released by Remix Therapeutics
  • 22 Apr 2026 Pharmacodynamics and adverse events data from a preclinical trial in Precursor-T-cell-lymphoblastic-leukaemia-lymphoma presented at the 117th Annual Meeting of the American Association for Cancer Research (AACR-2026)

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