Drug Profile

Berzanoflast - AstraZeneca

Alternative Names: AZD-4144

Latest Information Update: 27 Aug 2026

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At a glance

Originator AstraZeneca
Class Alcohols; Amines; Anti-inflammatories; Cardiovascular therapies; Fluorocarbons; Obesity therapies; Phthalazines; Small molecules; Urologics
Mechanism of Action NLRP3 protein inhibitors

Orphan Drug Status

Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

No
New Molecular Entity Yes

24 Aug 2026 AstraZeneca plans a phase I Pharmacokinetics trial in USA (PO) (NCT07783308)
30 Jul 2026 AstraZeneca initiates a phase I pharmacokinetics trial (In volunteers) in the United Kingdom (NCT07685600)
07 Jul 2026 Chemical structure information added

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