Drug Profile

Berzanoflast - AstraZeneca

Alternative Names: AZD-4144

Latest Information Update: 07 Jul 2026

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At a glance

Originator AstraZeneca
Class Alcohols; Amines; Anti-inflammatories; Cardiovascular therapies; Fluorocarbons; Obesity therapies; Phthalazines; Small molecules; Urologics
Mechanism of Action NLRP3 protein inhibitors

Orphan Drug Status

Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

No
New Molecular Entity Yes

07 Jul 2026 Chemical structure information added
06 Jul 2026 AstraZeneca plans a phase I trial (In Volunteers) in July 2026 (PO, IV) (NCT07685600)
26 May 2026 AstraZeneca completes a phase I pharmacokinetic trial in Kidney disorders (In volunteers) in United Kingdom (PO) (NCT07518459)

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