Drug Profile

AZD 4144

Alternative Names: AZD-4144

Latest Information Update: 15 Oct 2025

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At a glance

Originator AstraZeneca
Class Anti-inflammatories; Cardiovascular therapies; Small molecules; Urologics
Mechanism of Action NLRP3 protein inhibitors

Orphan Drug Status

Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

No
New Molecular Entity Yes

10 Oct 2025 AstraZeneca plans a phase-II SERENIA trial for Acute kidney injury (In adults, In the elderly) in USA, Argentina, Belgium, Canada, Czech republic, Denmark, France, Germany, Greece, Hungary, Spain, Turkey and United Kingdom (IV infusion) , (NCT07215702)
29 Sep 2025 AstraZeneca completes a phase I trial in Obesity in Germany (PO) (NCT06942923)
12 Jun 2025 AstraZeneca completes a phase I pharmacokinetic trial (In volunteers) in United Kingdom (PO) (NCT06925854)

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