Drug Profile

S 4321

Alternative Names: PD-1-FcγRIIb; S-4321

Latest Information Update: 11 Mar 2026

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At a glance

Originator Seismic Bio
Class Bispecific antibodies
Mechanism of Action Fc gamma receptor IIB agonists; Programmed cell death 1 receptor agonists

Orphan Drug Status

Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

No
New Molecular Entity Yes

Highest Development Phases

Phase I Autoimmune disorders

Most Recent Events

06 Mar 2026 Seismic Bio plans a phase I trial for Rheumatoid arthritis, Psoriatic arthritis, Psoriasis, Plaque psoriasis, Cutaneous lupus erythematosus, and Atopic dermatitis in February 2026 (SC) (NCT07455578)
03 Apr 2025 Phase-I clinical trials in Autoimmune disorders (In volunteers) in Australia (IV) (NCT06877611)
03 Apr 2025 Phase-I clinical trials in Autoimmune disorders (In volunteers) in Australia (SC) (NCT06877611)

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