Drug Profile

VX 828

Alternative Names: VX-828

Latest Information Update: 22 Aug 2025

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At a glance

Originator Vertex Pharmaceuticals
Class Antifibrotics; Small molecules
Mechanism of Action Cystic fibrosis transmembrane conductance regulator modulators

Orphan Drug Status

Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

No
New Molecular Entity Yes

04 Aug 2025 Vertex Pharmaceuticals plans a clinical trial for Cystic fibrosis (Combination therapy) in December 2025
05 May 2025 Vertex Pharmaceuticals completes phase-I clinical trial in Cystic fibrosis (In volunteers) in USA (PO, Suspension) (NCT06861413)
01 Apr 2025 Phase-I clinical trials in Cystic fibrosis (In volunteers) in USA (PO, Tablet) (NCT06861413)

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