Drug Profile

PLX 4545

Alternative Names: PLX-4545

Latest Information Update: 11 Jun 2025

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At a glance

Originator Plexium
Class Antineoplastics; Small molecules
Mechanism of Action IKZF2 protein degraders

Orphan Drug Status

Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

No
New Molecular Entity Yes

Highest Development Phases

Phase I Solid tumours

Most Recent Events

25 Apr 2025 Pharmacodynamics data from a preclinical studies in Solid tumour presented at the 116th Annual Meeting of the American Association for Cancer Research (AACR-2025)
25 Apr 2025 Pharmacodynamics data from a phase I trial in Solid tumour presented at the 116^th Annual Meeting of the American Association for Cancer Research (AACR-2025)
21 Nov 2023 Phase-I clinical trials in Solid tumours (In volunteers) in Australia (PO) (ACTRN12623001265662)

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