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VS 7375

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Drug Profile

VS 7375

Alternative Names: GFH-375; GFH375/VS-7375; VS-7375

Latest Information Update: 05 May 2026

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At a glance

  • Originator GenFleet Therapeutics
  • Developer GenFleet Therapeutics; Verastem Oncology
  • Class Antineoplastics; Small molecules
  • Mechanism of Action KRAS protein inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Phase III Pancreatic cancer
  • Phase I/II Solid tumours

Most Recent Events

  • 28 Apr 2026 Genfleet Therapeutics plans a phase II trial for Non-small cell lung cancer (Monotherapy, Combination therapy, Late-stage disease, First-line therapy) in China (PO) (NCT07554859) in May 2026
  • 17 Mar 2026 Pharmacodynamics data from a preclinical study in Pancreatic cancer released by Verastem Oncology
  • 04 Mar 2026 US FDA gives recent feedback on amending the VS-7375-101 phase I/II protocol to separate out disease-specific trials in combination with cetuximab

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