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VS 7375

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Drug Profile

VS 7375

Alternative Names: GFH-375; GFH375/VS-7375; VS-7375

Latest Information Update: 21 Aug 2025

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At a glance

  • Originator GenFleet Therapeutics
  • Developer GenFleet Therapeutics; Verastem Oncology
  • Class Antineoplastics; Small molecules
  • Mechanism of Action KRAS protein inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Phase I/II Solid tumours

Most Recent Events

  • 13 Aug 2025 Updated efficacy and adverse events data from a phase I/II trial in Solid tumours released by Verastem Oncology
  • 24 Jul 2025 VS 7375 receives Fast track designation status for Adenocarcinoma (First-line therapy, Late-stage disease, Metastatic disease) in USA
  • 24 Jul 2025 VS 7375 receives Fast track designation status for Adenocarcinoma (Second-line therapy or greater, Late-stage disease, Metastatic disease) in USA

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