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VS 7375

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Drug Profile

VS 7375

Alternative Names: GFH-375; GFH375/VS-7375; VS-7375

Latest Information Update: 25 Jun 2025

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At a glance

  • Originator GenFleet Therapeutics
  • Developer GenFleet Therapeutics; Verastem Oncology
  • Class Antineoplastics; Small molecules
  • Mechanism of Action KRAS protein inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Phase I/II Solid tumours

Most Recent Events

  • 18 Jun 2025 Genfleet Therapeutics plans a phase II trial for Pancreatic cancer (Monotherapy, Second-line therapy or greater, Metastatic disease) in August 2025 (PO) (NCT07026916)
  • 02 Jun 2025 Efficacy and adverse event data from a phase I trial in Solid tumours released by Verastem Oncology
  • 22 May 2025 Phase-I/II clinical trials in Solid tumours (Late-stage disease, Metastatic disease, Inoperable/Unresectable, Monotherapy, Second-line therapy or greater) in USA (PO) (NCT07020221)

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