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QHL 108

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Drug Profile

QHL 108

Alternative Names: Legubicin - Shanghai Affinity Biopharmaceutical; QHL-108

Latest Information Update: 09 Apr 2026

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At a glance

  • Originator Shanghai Affinity Biopharmaceutical
  • Class Anthracyclines; Antineoplastics; Cytostatic antibiotics; Doxorubicins; Drug conjugates
  • Mechanism of Action DNA intercalators; Type II DNA topoisomerase inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes
  • Available For Licensing Yes

Highest Development Phases

  • Phase II/III Soft tissue sarcoma
  • Phase II Adenocarcinoma
  • Preclinical Solid tumours

Most Recent Events

  • 17 Oct 2025 Efficacy and adverse events data from a phase II/III trial in Soft tissue sarcoma presented at the 50th European Society for Medical Oncology Congress (ESMO-2025)
  • 03 Jun 2025 Shanghai Affinity Biomedical Technology completes phase-II/III clinical trials in Soft tissue sarcoma (Late-stage disease, Inoperable/Unresectable, Recurrent, Metastatic disease) in China (Parenteral) (CTR20212527)
  • 22 Dec 2023 QHL 108 is available for licensing as of 22 Dec 2023. http://www.affinitybiopharma.com/en/cooperation.html (Shanghai Affinity Biopharmaceutical website, December 2023)

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