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XL 495

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Drug Profile

XL 495

Alternative Names: XL-495

Latest Information Update: 27 Jun 2025

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At a glance

  • Originator Exelixis
  • Class Antineoplastics; Small molecules
  • Mechanism of Action PKMYT1 protein inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Discontinued Solid tumours

Most Recent Events

  • 25 Jun 2025 Exelixis terminated phase I for Solid tumours (Late-stage disease, Metastatic disease, Combination therapy, Second-line therapy or greater) in USA due to company decision (PO) (NCT06630247)
  • 25 Jun 2025 Exelixis terminated phase I for Solid tumours (Late-stage disease, Metastatic disease, Monotherapy, Second-line therapy or greater) in USA due to company decision (PO) (NCT06630247)
  • 13 May 2025 Discontinued - Phase-I for Solid tumours (Combination therapy, Late-stage disease, Metastatic disease, Second-line therapy or greater) in USA (PO) (NCT06630247)

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