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TRX 103

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Drug Profile

TRX 103

Alternative Names: TRX-103

Latest Information Update: 10 Sep 2026

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At a glance

  • Originator Tr1X
  • Class Gene therapies; Regulatory T lymphocyte cell therapies
  • Mechanism of Action Interleukin-10 expression stimulants; Regulatory T-lymphocyte replacements
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Graft-versus-host disease
  • New Molecular Entity No

Highest Development Phases

  • Phase I/II Crohn's disease; Graft-versus-host disease
  • Preclinical Immune-mediated uveitis; Inflammatory bowel diseases

Most Recent Events

  • 03 Sep 2026 TRX 103 receives Fast Track designation for Crohn's disease [Parenteral] (Treatment-experienced) in USA before September 2026 (TR1X pipeline, September 2026)
  • 27 Apr 2026 Updated adverse events, pharmacodynamics data from a phase I trial in Graft versus host disease released by Tr1X
  • 29 Mar 2026 TRX 103 receives Orphan Drug status for Graft-versus-host disease (Prevention) in USA (Tr1X Bio pipeline, March 2026)

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