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LY 4052031

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Drug Profile

LY 4052031

Alternative Names: LY-4052031

Latest Information Update: 23 Jul 2026

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At a glance

  • Originator Eli Lilly and Company
  • Class Antineoplastics; Drug conjugates; Immunoconjugates; Monoclonal antibodies
  • Mechanism of Action DNA topoisomerase I inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Phase I Solid tumours

Most Recent Events

  • 29 May 2026 Efficacy and adverse event data from a phase Ia/Ib NEXUS-01 trial in Solid tumours presented at the 62nd Annual Meeting of the American Society of Clinical Oncology (ASCO-2026)
  • 25 Sep 2025 Eli Lilly and Company reinitiates the phase I NEXUS-01 trial in Solid tumours (Metastatic disease, Late-stage disease) in the US, UK, Australia, France, Japan, South Korea, Spain (IV) (NCT06465069)
  • 21 Apr 2025 Eli Lilly and Company terminates the phase I NEXUS-01 trial in Solid tumours (Metastatic disease, Late-stage disease) in the US, UK, Australia, France, Japan, South Korea, Spain (IV), due to sponsor decision (NCT06465069)

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