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BF 114

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Drug Profile

BF 114

Alternative Names: BF-114; siRNA targeting Beta2-spectrin - BullFrog AI

Latest Information Update: 28 Feb 2026

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At a glance

  • Originator The George Washington University
  • Developer BullFrog AI
  • Class Antineoplastics; Hepatoprotectants; Obesity therapies; Small interfering RNA
  • Mechanism of Action RNA interference; SPTBN1 protein expression inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes
  • Available For Licensing Yes

Highest Development Phases

  • Preclinical Obesity
  • No development reported Liver cancer; Non-alcoholic fatty liver disease; Non-alcoholic steatohepatitis

Most Recent Events

  • 28 Feb 2026 No recent reports of development identified for research development in Liver-cancer in USA (Parenteral)
  • 28 Feb 2026 No recent reports of development identified for research development in Non-alcoholic-fatty-liver-disease in USA (Parenteral)
  • 28 Feb 2026 No recent reports of development identified for research development in Non-alcoholic-steatohepatitis in USA (Parenteral)

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