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ADRX 0405

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Drug Profile

ADRX 0405

Alternative Names: ADRX-0405

Latest Information Update: 10 Jul 2025

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At a glance

  • Originator Adcentrx Therapeutics
  • Class Antibodies; Antineoplastics; Drug conjugates; Immunoconjugates
  • Mechanism of Action Antibody-dependent cell cytotoxicity; DNA topoisomerase I inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Gastric cancer
  • New Molecular Entity Yes

Highest Development Phases

  • Phase I Solid tumours

Most Recent Events

  • 08 Jul 2025 ADRX 0405 receives Orphan Drug status for Gastric cancer in USA
  • 25 Apr 2025 Pharmacodynamics data from a preclinical studies in Solid tumours presented at the 116th Annual Meeting of the American Association for Cancer Research (AACR-2025)
  • 29 Nov 2024 Phase-I clinical trials in Solid tumours (Late-stage disease, Second-line therapy or greater, Metastatic disease, Hormone refratory) in USA (Parenteral) (NCT06710379)

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