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ASP 4396

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Drug Profile

ASP 4396

Alternative Names: ASP-4396

Latest Information Update: 19 Feb 2026

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At a glance

  • Originator Astellas Pharma
  • Class Antineoplastics; Small molecules
  • Mechanism of Action KRAS protein degraders
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Discontinued Solid tumours

Most Recent Events

  • 04 Feb 2026 Discontinued - Phase-I for Solid tumours (Inoperable/Unresectable, Late-stage disease, Metastatic disease, Second-line therapy or greater) in USA to focus development on other candidates (IV) (Astellas Pharma pipeline, February 2026)
  • 22 Oct 2025 Pharmacodynamics data from a preclinical study in Cancer presented at the AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics 2025 (AACR-NCI-EORTC-2025)
  • 16 Apr 2024 Phase-I clinical trials in Solid tumours (Late-stage disease, Inoperable/Unresectable, Metastatic disease, Second-line therapy or greater) in USA (IV) (NCT06364696)

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