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CGX 195

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Drug Profile

CGX 195

Alternative Names: Alpha-1-antitrypsin-deficiency therapeutics - Congruence Therapeutics; CGX-195

Latest Information Update: 11 Sep 2026

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At a glance

  • Originator Congruence Therapeutics
  • Class Small molecules
  • Mechanism of Action Alpha 1-antitrypsin modulators
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Preclinical Alpha 1-antitrypsin deficiency

Most Recent Events

  • 11 Sep 2026 Congruence Therapeutics plans a phase I trial for Alpha 1-antitrypsin deficiency in 2027 (Congruence Therapeutics pipeline, September 2026)
  • 31 Mar 2026 Pharmacodynamics data from a preclinical trial in Alpha 1-antitrypsin deficiency released by Congruence Therapeutics(Congruence Therapeutics pipeline, March 2026)
  • 19 Mar 2026 Congruence Therapeutics plans to file an IND/CTA application for Alpha-1 antitrypsin deficiency therapeutics in early 2027

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