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GEN 1055

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Drug Profile

GEN 1055

Alternative Names: BNT-315; GEN-1055; HexaBody-OX40

Latest Information Update: 07 Jan 2026

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At a glance

  • Originator Genmab
  • Developer BioNTech; Genmab
  • Class Antibodies; Antineoplastics; Immunotherapies
  • Mechanism of Action OX40 ligand modulators
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Phase I/II Solid tumours

Most Recent Events

  • 26 Dec 2025 Genmab terminates phase-I/II clinical trials in Solid tumours (Late-stage disease, Metastatic disease, Second-line therapy or greater, Combination therapy, Monotherapy) in USA and Spain (IV) (NCT06391775)
  • 14 May 2024 Phase-I/II clinical trials in Solid tumours (Late-stage disease, Metastatic disease, Monotherapy, Second-line therapy or greater) in USA (IV) (NCT06391775)
  • 14 May 2024 Phase-I/II clinical trials in Solid tumours (Late-stage disease, Metastatic disease, Second-line therapy or greater, Combination therapy) in USA (IV) (NCT06391775)

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