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ALN ANG3

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Drug Profile

ALN ANG3

Alternative Names: ALN-ANG3

Latest Information Update: 20 Feb 2026

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At a glance

  • Originator Alnylam Pharmaceuticals
  • Developer Alnylam Pharmaceuticals; Regeneron Pharmaceuticals
  • Class Cardiovascular therapies; Small interfering RNA
  • Mechanism of Action ANGPTL3 protein expression inhibitors; RNA interference
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Diabetic nephropathies
  • Phase I Cardiovascular disorders; Metabolic disorders

Most Recent Events

  • 09 Jan 2026 Phase-II clinical trials in Diabetic nephropathies (Combination therapy) in USA (Parenteral) (NCT07271186)
  • 09 Jan 2026 Phase-II clinical trials in Diabetic nephropathies (Monotherapy) in USA (Parenteral) (NCT07271186)
  • 09 Dec 2025 Regeneron Pharmaceuticals plans a phase II ANCHOR-POC trial for Diabetic-nephropathies (Monotherapy, Combination therapy) in December 2025 (NCT07271186)

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