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DSB 2455

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Drug Profile

DSB 2455

Alternative Names: DSB-2455

Latest Information Update: 02 Apr 2026

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At a glance

  • Originator Duke Street Bio
  • Class Antineoplastics; Small molecules
  • Mechanism of Action Poly(ADP-ribose) polymerase-1 inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Phase I Solid tumours

Most Recent Events

  • 30 Oct 2024 Phase-I clinical trials in Solid tumours (Second-line therapy or greater, Late-stage disease, Metastatic disease) in Spain (PO) (NCT06458712)
  • 23 Oct 2024 Safety, pharmacokinetics and pharmacodynamics data from a preclinical trial in Solid tumours presented at the 36th EORTC-NCI-AACR Symposium on molecular targets and cancer therapeutics (EORTC-NCI-AACR-2024)
  • 14 Jun 2024 Duke Street Bio plans a phase I trial for Solid tumours (Monotherapy, Combination-therapy, Late-stage disease, Second-line therapy or grater, Metastatic disease) (PO), in September 2024 (NCT06458712)

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