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VHB 937

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Drug Profile

VHB 937

Alternative Names: VHB-937

Latest Information Update: 13 Feb 2026

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At a glance

  • Originator Novartis; Novartis Institutes for BioMedical Research
  • Class Anti-inflammatories; Antidementias; Monoclonal antibodies; Neuroprotectants
  • Mechanism of Action TREM2 protein-stimulants
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Alzheimer's disease; Amyotrophic lateral sclerosis
  • Preclinical Inflammation; Multiple sclerosis; Neurodegenerative disorders

Most Recent Events

  • 31 Dec 2025 Novartis intends to file regulatory applications for the approval of VHB 937 in Alzheimer's disease and Amyotrophic lateral sclerosis in or after 2029 (Novartis pipeline, December 2025)
  • 24 Sep 2025 Preclinical trials in Inflammation in USA (IV), prior to September 2025
  • 24 Sep 2025 Preclinical trials in Multiple sclerosis in USA (IV), prior to September 2025

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