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VHB 937

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Drug Profile

VHB 937

Alternative Names: VHB-937

Latest Information Update: 03 Nov 2025

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At a glance

  • Originator Novartis; Novartis Institutes for BioMedical Research
  • Class Antidementias; Monoclonal antibodies
  • Mechanism of Action TREM2 protein-stimulants
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Alzheimer's disease; Amyotrophic lateral sclerosis

Most Recent Events

  • 07 Aug 2025 Phase-II clinical trials in Alzheimer's disease (In adults, In the elderly) in United Kingdom, Canada, USA (IV) (NCT07094516)
  • 30 Jul 2025 Novartis plans a phase II trial for Alzheimer's disease (IV, Infusion), in September 2025 (NCT07094516)
  • 06 Jul 2025 Phase-II clinical trials in Amyotrophic lateral sclerosis in United Kingdom, Switzerland, Sweden, Spain, Poland, Netherlands, South Korea, Japan, Ireland, Germany, France, Denmark, China, Canada, Belgium, Australia, USA (IV) (Novartis pipeline, July 2025)

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