Drug Profile

ORN 252

Alternative Names: Anti-CD19 CAR therapy - Orna Therapeutics; ORN-252

Latest Information Update: 10 Apr 2026

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At a glance

Originator Orna Therapeutics
Class CAR-T cell therapies; Circular RNA; Gene therapies; Immunotherapies
Mechanism of Action T lymphocyte replacements

Orphan Drug Status

Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

No
New Molecular Entity No

Highest Development Phases

Phase I Autoimmune disorders

Most Recent Events

31 Mar 2026 Phase-I clinical trials in Autoimmune disorders (In volunteers) in USA (Parenteral) (NCT07439796)
07 Dec 2025 Pharmacodynamics data from a preclinical study in Autoimmune disorders released by Orna Therapeutics
03 Nov 2025 Orna Therapeutics plans to file clinical trial application in the fourth quarter of 2025

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