Drug Profile

FoRx 428

Alternative Names: FoRx-06-428; FoRx-428

Latest Information Update: 26 Dec 2025

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At a glance

Originator FoRx Therapeutics
Class Antineoplastics; Small molecules
Mechanism of Action Poly ADP ribose glycohydrolase inhibitors

Orphan Drug Status

Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

No
New Molecular Entity Yes

Highest Development Phases

Phase I Solid tumours

Most Recent Events

22 Oct 2025 Pharmacodynamics data from a preclinical trial in Solid tumours presented at the AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics 2025 (AACR-NCI-EORTC-2025)
11 Aug 2025 Phase-I clinical trials in Solid tumours (Second-line therapy or greater) in USA (PO)
11 Aug 2025 FoRx Therapeutics anticipates IND clearance from the US FDA by mid-2025

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