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FoRx 428

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Drug Profile

FoRx 428

Alternative Names: FoRx-06-428; FoRx-428

Latest Information Update: 20 Aug 2025

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At a glance

  • Originator FoRx Therapeutics
  • Class Antineoplastics; Small molecules
  • Mechanism of Action Poly ADP ribose glycohydrolase inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Phase I Solid tumours

Most Recent Events

  • 11 Aug 2025 Phase-I clinical trials in Solid tumours (Second-line therapy or greater) in USA (PO)
  • 11 Aug 2025 FoRx Therapeutics anticipates IND clearance from the US FDA by mid-2025
  • 13 Jun 2025 FORX 428 receives investigational new drug (IND) clearance from the US FDA for phase I trial in solid tumours

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